Article
Drug resistance and viral tropism in HIV-1 subtype C-infected patients in KwaZulu-Natal, South Africa: implications for future treatment options.
Journal of acquired immune deficiency syndromes (1999) - 1 Nov 2011
Singh Ashika, Sunpath Henry, Green Taryn N, Padayachi Nagavelli, Hiramen Keshni, Lie Yolanda, Anton Elizabeth D, Murphy Richard, Reeves Jacqueline D, Kuritzkes Daniel R, Ndung'u Thumbi
Abstract excerpt
BACKGROUND: Drug resistance poses a significant challenge for the successful application of highly active antiretroviral therapy (HAART) globally. Furthermore, emergence of HIV-1 isolates that preferentially use CXCR4 as a coreceptor for cell entry, either as a consequence of natural viral evolution or HAART use, may compromise the efficacy of CCR5 antagonists as alternative antiviral therapy. METHODS: We...
Topics
- Adult
- Aged
- Anti-HIV Agents
- Drug Resistance, Viral
- Female
- Genotype
- HIV Infections
- HIV-1
- Humans
- Male
- Middle Aged