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Article

Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain Tumors

13 Apr 2018

Abstract excerpt

Abstract Brain tumors remain the leading cause of cancer-related deaths in children and often are associated with long-term sequelae among survivors of current therapies. Hence, there is an urgent need to identify actionable targets and to develop more effective therapies. Telomerase and telomeres play important roles in cancer, representing attractive therapeutic targets to treat children with poor-prognosis...

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Share to DNA Repair Mechanisms
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PMID: 29654065
DOI: 10.1158/1535-7163.mct-17-0792

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