Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of Telomere Maintenance in the Spontaneous Growth Arrest of Pediatric Low-Grade Gliomas

1 Feb 2006

Abstract excerpt

Spontaneous tumor regression of pediatric low-grade gliomas (PLGG). We speculated that lack of telomere maintenance is responsible for this behavior. We first looked for evidence of telomerase activity and alternative lengthening of telomeres (ALT) in 56 PLGG. Telomerase activity was observed in 0 of 11 PLGG, in contrast to 10 of 13 high-grade pediatric brain tumors. There was no ALT in 45 of 45 samples. We then...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mitochondrial Function and Pathology
Share to Radiation Therapy and Dosimetry
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16611406
DOI: 10.1593/neo.05715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of Telomere Maintenance in the Spontaneous Growth Arrest of Pediatric Low-Grade GliomasPMID 16611406Read ↗

Mechanisms of telomere maintenance and associated therapeutic vulnerabilities in malignant gliomasSemantic proximity Read ↗

Molecular Mechanism of Telomere Length Dynamics and Its Prognostic Value in Pediatric Cancers.Semantic proximity Read ↗

Alternative lengthening of telomeres (ALT) in pediatric high-grade gliomas can occur without ATRX mutation and is enriched in patients with pathogenic germline mismatch repair (MMR) variants.Semantic proximity Read ↗

Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric malignant brain tumors.Semantic proximity Read ↗

Telomere maintenance and the etiology of adult gliomaSemantic proximity Read ↗

Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain TumorsSemantic proximity Read ↗

Telomere maintenance and dysfunction predict recurrence in paediatric ependymomaSemantic proximity Read ↗

Telomerase Activity in Human GliomasSemantic proximity Read ↗

Telomerase Activity and Telomere Length in Primary and Metastatic Tumors from Pediatric Bone Cancer PatientsSemantic proximity Read ↗

Alternative lengthening of telomeres—An enhanced chromosomal instability in aggressive non‐MYCN amplified and telomere elongated neuroblastomasSemantic proximity Read ↗

Telomerase activity and telomere length in pediatric patients with malignancies undergoing chemotherapySemantic proximity Read ↗

Resection extent and BRAF V600E mutation status determine postoperative tumor growth velocity in pediatric low-grade glioma: results from a single-center cohort analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.