Article

Inhibiting sirtuin-dependent DNA repair and oxidative stress responses impairs DIPG cell survival

2025-11-21

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : Diffuse intrinsic pontine gliomas (DIPG) are universally fatal pediatric brain tumors often characterized by a H3 histone mutation (H3K27M) that leads to epigenetic alterations and gene dysregulation. Histone deacetylases (HDAC), key players in modulating epigenetic pathways in cancer, have emerged as potential therapeutic targets for DIPG. This study evalua...

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Literature Corpus work: 327e6a34-1760-562c-a5d3-bbae142c2d8f
DOI: 10.21203/rs.3.rs-7723497/v1

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