Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence

18 Sept 2023

Abstract excerpt

Therapeutic resistance remains a major obstacle to successful clinical management of diffuse intrinsic pontine glioma (DIPG), a high-grade pediatric tumor of the brain stem. In nearly all patients, available therapies fail to prevent progression. Innovative combinatorial therapies that penetrate the blood-brain barrier and lead to long-term control of tumor growth are desperately needed. We identified mechanisms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to DNA Repair Mechanisms
Share to Glioma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37723046
DOI: 10.1158/1535-7163.mct-23-0026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor RecurrencePMID 37723046Read ↗

Diffuse Intrinsic Pontine Glioma : Clinical Features, Molecular Genetics, and Novel Targeted TherapeuticsSemantic proximity Read ↗

Diffuse intrinsic pontine glioma: current insights and future directionsSemantic proximity Read ↗

Diffuse Intrinsic Pontine Glioma: New Pathophysiological Insights and Emerging Therapeutic Targets.Semantic proximity Read ↗

Developing H3K27M mutant selective radiosensitization strategies in diffuse intrinsic pontine glioma.Semantic proximity Read ↗

The Molecular, Neurological, and Clinical Features of Diffuse Intrinsic Pontine GliomaSemantic proximity Read ↗

Epigenetic Targeted Therapy for Diffuse Intrinsic Pontine GliomaSemantic proximity Read ↗

Microtubule-Targeting Combined with HDAC Inhibition Is a Novel Therapeutic Strategy for Diffuse Intrinsic Pontine Gliomas.Semantic proximity Read ↗

Children are not just little adults: recent advances in understanding of diffuse intrinsic pontine glioma biology.Semantic proximity Read ↗

A High-Throughput In Vitro Drug Screen in a Genetically Engineered Mouse Model of Diffuse Intrinsic Pontine Glioma Identifies BMS-754807 as a Promising Therapeutic AgentSemantic proximity Read ↗

Inhibition of mutant PPM1D enhances DNA damage response and growth suppressive effects of ionizing radiation in diffuse intrinsic pontine gliomaSemantic proximity Read ↗

Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine GliomaSemantic proximity Read ↗

Efficacy of chemoradiotherapy in pediatric H3K27M-mutant diffuse intrinsic pontine glioma: a study based on single-center and SEER data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.