Article
KIR3DL1+HLA-B Bw4Ile80 and KIR2DS1+HLA-C2 combinations are both associated with ankylosing spondylitis in the Iranian population.
International journal of immunogenetics - 1 Oct 2011
Tajik N, Shahsavar F, Poormoghim H, Radjabzadeh M F, Mousavi T, Jalali A
Abstract excerpt
Contribution of killer cell immunoglobulin-like receptors (KIR) and their human leucocyte antigen (HLA) class I ligands in the pathogenesis of autoimmune diseases has been shown in several studies. In this study, the possible association of KIR genes, their known HLA ligands and compound KIR/HLA genotypes with ankylosing spondylitis (AS) was assessed. Combined KIR/HLA ligand genotyping was performed by a...
Topics
- Adolescent
- Adult
- Child
- Gene Frequency
- Genetic Predisposition to Disease
- Genetics, Population
- HLA-B Antigens
- HLA-C Antigens
- Humans
- Iran
- Male