Article
Integrated Post-GWAS Analysis Sheds New Light on the Disease Mechanisms of Schizophrenia.
Genetics - 1 Dec 2016
Lin Jhih-Rong, Cai Ying, Zhang Quanwei, Zhang Wen, Nogales-Cadenas Rubén, Zhang Zhengdong D
Abstract excerpt
Schizophrenia is a severe mental disorder with a large genetic component. Recent genome-wide association studies (GWAS) have identified many schizophrenia-associated common variants. For most of the reported associations, however, the underlying biological mechanisms are not clear. The critical first step for their elucidation is to identify the most likely disease genes as the source of the association signals....
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