Article
Improving treatment outcome assessment in a mouse tuberculosis model.
Scientific reports - 9 Apr 2018
Mourik Bas C, Svensson Robin J, de Knegt Gerjo J, Bax Hannelore I, Verbon Annelies, Simonsson Ulrika S H, de Steenwinkel Jurriaan E M
Abstract excerpt
Preclinical treatment outcome evaluation of tuberculosis (TB) occurs primarily in mice. Current designs compare relapse rates of different regimens at selected time points, but lack information about the correlation between treatment length and treatment outcome, which is required to efficiently estimate a regimens' treatment-shortening potential. Therefore we developed a new approach. BALB/c mice were infected...
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