Establishing translational performance standards for TB therapy using rifampicin-based regimens in a male and female high-burden murine model

Abstract excerpt

BACKGROUND: Establishing efficacy benchmarks in preclinical tuberculosis (TB) models is essential for optimizing and prioritizing therapeutic regimens. However, standardized classification methods for comparing high-performing regimens are currently lacking. This study defines a quantitative framework utilizing rifampicin-based regimens in a high-burden aerosol BALB/c mouse model, incorporating both male and...

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