Article

The design, analysis and application of mouse clinical trials in oncology drug development

2018-09-24

Abstract excerpt

Mouse clinical trials (MCTs) are becoming widely used in pre-clinical oncology drug development. In this study, we provide some general guidelines on the design, analysis and application of MCTs. We first established empirical quantitative relationships between mouse number and measurement accuracy for both categorical and continuous efficacy endpoints, and showed that more mice are needed to achieve given accurac...

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Literature Corpus work: d080c4ae-db12-54bf-b607-3c80570b347b
DOI: 10.1101/425256

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