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PARP-1 Expression is Increased in Colon Adenoma and Carcinoma and Correlates with OGG1

19 Dec 2014

Abstract excerpt

The ethiology of colon cancer is largely dependent on inflammation driven oxidative stress. The analysis of 8-oxodeoxyguanosine (8-oxodGuo) level in leukocyte DNA of healthy controls (138 individuals), patients with benign adenomas (AD, 137 individuals) and with malignant carcinomas (CRC, 169 individuals) revealed a significant increase in the level of 8-oxodGuo in leukocyte DNA of AD and CRC patients in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25526641
DOI: 10.1371/journal.pone.0115558

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