Article
In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants.
Biochemical pharmacology - 1 Jun 2018
Nakanishi Kazuyuki, Uehara Shotaro, Kusama Takashi, Inoue Takashi, Shimura Kanami, Kamiya Yusuke, Murayama Norie, Shimizu Makiko, Uno Yasuhiro, Sasaki Erika, Yamazaki Hiroshi
Abstract excerpt
Common marmosets (Callithrix jacchus) are potentially useful nonhuman primate models for preclinical studies. An anti-inflammatory drug, diclofenac is reportedly metabolized mainly by human cytochrome P450 (P450) 2C9 to 4'-hydroxydiclofenac and minorly by P450 3A4 to 5-hydroxydiclofenac that leads to reactive intermediates. In this study, in vivo pharmacokinetics in six marmosets and in vitro metabolism in nine...
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