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Article

Metabolism of 18-methoxycoronaridine, an ibogaine analog, to 18-hydroxycoronaridine by genetically variable CYP2C19.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jun 2002

Zhang Wenjiang, Ramamoorthy Yamini, Tyndale Rachel F, Glick Stanley D, Maisonneuve Isabelle M, Kuehne Martin E, Sellers Edward M

Abstract excerpt

18-Methoxycoronaridine, a newly developed ibogaine analog, has been reported to decrease the self-administration of morphine, cocaine, ethanol, and nicotine. It has also been reported to attenuate naltrexone-precipitated signs of morphine withdrawal. In this study, three metabolites of 18-methoxycoronaridine (18-MC) were separated and identified by high-performance liquid chromatography-electrospray...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cytochrome P-450 CYP2C19

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Share to Oxidoreductases, N-Demethylating

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Source

Identifiers

PMID: 12019193
DOI: 10.1124/dmd.30.6.663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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