Article
Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Apr 2021
Matsumoto Shogo, Uehara Shotaro, Kamimura Hidetaka, Ikeda Hiroshi, Maeda Satoshi, Hattori Machiko, Nishiwaki Megumi, Kato Kazuhiko, Yamazaki Hiroshi
Abstract excerpt
Common marmosets (Callithrix jacchus) are small non-human primates that genetically lack cytochrome P450 2C9 (CYP2C9). Polymorphic marmoset CYP2C19 compensates by mediating oxidations of typical human CYP2C9/19 substrates.Twenty-four probe substrates were intravenously administered in combinations to marmosets assigned to extensive or poor metaboliser (PM) groups by CYP2C19 genotyping. Eliminations from plasma of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.