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Phenotyping by Molecular Mobility: Low-Affinity Reversible Probes Enable Characterizing and Classifying Cells Populations by Single-Molecule Imaging.

Journal of the American Chemical Society - 1 Apr 2026

Riera Roger, Fitzpatrick Laurence W, Huet Simon, Tholen Marrit M E, Jacquot Perrine, Cinier Mathieu, Woythe Laura, Tanou Marine, Izquierdo-Lozano Cristina, Verhoeven Mats, Albertazzi Lorenzo

Abstract excerpt

Cell surface biomolecules, such as membrane receptors, are key drivers of cellular behavior and are therefore inherently different for cell types with different functions and pathogenicity. Here, we present a super-resolution method for functional phenotyping of cell populations based on the single-molecule analysis of membrane receptor mobility. Central to our approach is a library of nanofitin-based...

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PMID: 41839769
DOI: 10.1021/jacs.5c11933

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