Article

Neurodegenerative disease associated pathways in brain of the triple transgenic Alzheimer’s model are reversed in vivo following two weeks peripheral administration of fasudil

2022-10-03

Abstract excerpt

The pan ROCK inhibitor fasudil acts as a vasodilator and has been used as a medication post cerebral stroke for the past 27 years in Japan and China. More recently, on the basis of the involvement of ROCK inhibition on synaptic function, neuronal survival and processes associated with neuroinflammation, it has been suggested that the drug may be repurposed for neurodegenerative diseases. Indeed, fasudil has demons...

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Literature Corpus work: 2b92ad4d-7059-56eb-94ba-8603219e0c2a
DOI: 10.1101/2022.09.30.510301

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Neurodegenerative disease associated pathways in brain of the triple transgenic Alzheimer’s model are reversed in vivo following two weeks peripheral administration of fasudilDOI 10.1101/2022.09.30.510301Read

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