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Article

Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study.

Toxicology and applied pharmacology - 1 Jun 2018

Balakrishnan Poojitha, Navas-Acien Ana, Haack Karin, Vaidya Dhananjay, Umans Jason G, Best Lyle G, Goessler Walter, Francesconi Kevin A, Franceschini Nora, North Kari E, Cole Shelley A, Voruganti V Saroja, Gribble Matthew O

Abstract excerpt

We explored arsenic-gene interactions influencing pancreatic beta-cell activity in the Strong Heart Family Study (SHFS). We considered 42 variants selected for associations with either beta-cell function (31 variants) or arsenic metabolism (11 variants) in the SHFS. Beta-cell function was calculated as homeostatic model - beta corrected for insulin resistance (cHOMA-B) by regressing homeostatic model - insulin...

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Identifiers

PMID: 29621497
DOI: 10.1016/j.taap.2018.03.034
PMCID: PMC5961497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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