Article
Genetic predisposition to impaired beta-cell function modifies the association between serum pyrethroid levels and the risk of type 2 diabetes: A gene-environment interaction study.
Ecotoxicology and environmental safety - 1 Oct 2024
Jia Chengyong, Zhang Shiyang, An Jun, Cheng Xu, Li Peiwen, Zhang Xin, Geng Tingting, Li Wending, Yan Yan, Zhao Zhuoya, Yang Handong, Yang Kun, Jing Tao, Guo Huan, Zhang Xiaomin, Wu Tangchun, He Meian
Abstract excerpt
Previous studies suggested that pyrethroid exposure was associated with elevated type 2 diabetes (T2D) risk, while it remains uncertain whether genetic predisposition modifies this association. A nested case-control study within the prospective Dongfeng-Tongji cohort comprised 1832 T2D cases, age- (±5 years) and sex-matched controls with qualified genotyping data. Serum pyrethroids were measured by gas...
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