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Article

Gene-environment interactions in the associations of PFAS exposure with insulin sensitivity and beta-cell function in a Faroese cohort followed from birth to adulthood.

Environmental research - 1 Jun 2023

Valvi Damaskini, Christiani David C, Coull Brent, Højlund Kurt, Nielsen Flemming, Audouze Karine, Su Li, Weihe Pal, Grandjean Philippe

Abstract excerpt

BACKGROUND: Exposure to perfluoroalkyl substances (PFAS) has been associated with changes in insulin sensitivity and pancreatic beta-cell function in humans. Genetic predisposition to diabetes may modify these associations; however, this hypothesis has not been yet studied. OBJECTIVES: To evaluate genetic heterogeneity as a modifier in the PFAS association with insulin sensitivity and pancreatic beta-cell...

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Source

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Identifiers

PMID: 36868448
DOI: 10.1016/j.envres.2023.115600
PMCID: PMC10101920

Genes

PFAS
FTO
ABCA1
PPARG
SLC12A3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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