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Article

Arsenic exposure and calpain-10 polymorphisms impair the function of pancreatic beta-cells in humans: a pilot study of risk factors for T2DM.

PloS one - 1 Jan 2013

Díaz-Villaseñor Andrea, Cruz Laura, Cebrián Arturo, Hernández-Ramírez Raúl U, Hiriart Marcia, García-Vargas Gonzálo, Bassol Susana, Sordo Monserrat, Gandolfi A Jay, Klimecki Walter T, López-Carillo Lizbeth, Cebrián Mariano E, Ostrosky-Wegman Patricia

Abstract excerpt

The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide and diverse environmental and genetic risk factors are well recognized. Single nucleotide polymorphisms (SNPs) in the calpain-10 gene (CAPN-10), which encodes a protein involved in the secretion and action of insulin, and chronic exposure to inorganic arsenic (iAs) through drinking water have been independently associated with an increase in...

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Identifiers

PMID: 23349674
DOI: 10.1371/journal.pone.0051642
PMCID: PMC3551951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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