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Article

IL1A rs1800587 associates with chronic noncrisis pain in sickle cell disease.

Pharmacogenomics - 1 Dec 2016

Hu Xiaoyu, Jhun Ellie H, Yao Yingwei, He Ying, Molokie Robert E, Wilkie Diana J, Wang Zaijie J

Abstract excerpt

AIM: Pain is prevalent in sickle cell disease (SCD) patients who display great heterogeneity in pain severity and frequency. Hypothesizing that inflammatory factors are involved in the pathogenesis of SCD pain, we focused on the IL1A C/T polymorphism rs1800587 that is an SNP located in a cis-transcriptional regulatory region. METHODS: We genotyped IL1A rs1800587 and performed association studies with phenotype...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27883292
DOI: 10.2217/pgs-2016-0085
PMCID: PMC5220521

Genes

SCD

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