SOX11 expression is restricted to EBV-negative Burkitt lymphoma and is associated with molecular genetic features.

doi:10.1182/blood.2023023242

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Article

SOX11 expression is restricted to EBV-negative Burkitt lymphoma and is associated with molecular genetic features.

Blood - 11 Jul 2024

Sureda-Gómez Marta, Iaccarino Ingram, De Bolòs Anna, Meyer Mieke, Balsas Patricia, Richter Julia, Rodríguez Marta-Leonor, López Cristina, Carreras-Caballé Maria, Glaser Selina, Nadeu Ferran, Jares Pedro, Clot Guillem, Siciliano Maria Chiara, Bellan Cristiana, Tornambè Salvatore, Boccacci Roberto, Leoncini Lorenzo, Campo Elias, Siebert Reiner, Amador Virginia, Klapper Wolfram

Abstract excerpt

ABSTRACT: SRY-related HMG-box gene 11 (SOX11) is a transcription factor overexpressed in mantle cell lymphoma (MCL), a subset of Burkitt lymphomas (BL) and precursor lymphoid cell neoplasms but is absent in normal B cells and other B-cell lymphomas. SOX11 has an oncogenic role in MCL but its contribution to BL pathogenesis remains uncertain. Here, we observed that the presence of Epstein-Barr virus (EBV) and...

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PMID: 38620074
DOI: 10.1182/blood.2023023242

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