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Article

FIGL1 and its novel partner FLIP form a conserved complex that regulates homologous recombination.

PLoS genetics - 1 Apr 2018

Fernandes Joiselle Blanche, Duhamel Marine, Seguéla-Arnaud Mathilde, Froger Nicole, Girard Chloé, Choinard Sandrine, Solier Victor, De Winne Nancy, De Jaeger Geert, Gevaert Kris, Andrey Philippe, Grelon Mathilde, Guerois Raphael, Kumar Rajeev, Mercier Raphaël

Abstract excerpt

Homologous recombination is central to repair DNA double-strand breaks, either accidently arising in mitotic cells or in a programed manner at meiosis. Crossovers resulting from the repair of meiotic breaks are essential for proper chromosome segregation and increase genetic diversity of the progeny. However, mechanisms regulating crossover formation remain elusive. Here, we identified through genetic and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29608566
DOI: 10.1371/journal.pgen.1007317
PMCID: PMC5897033

Genes

DMC1
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FIGL1 and its novel partner FLIP form a conserved complex that regulates homologous recombination.PMID 29608566Read ↗

FIGL1 and its novel partner FLIP form a conserved complex that regulates homologous recombinationSemantic proximity Read ↗

AAA-ATPase FIDGETIN-LIKE 1 and Helicase FANCM Antagonize Meiotic Crossovers by Distinct Mechanisms.Semantic proximity Read ↗

FIGL1 attenuates meiotic interhomolog repair and is counteracted by the RAD51 paralog XRCC2 and the chromosome axis protein ASY1 during meiosis.Semantic proximity Read ↗

The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restartSemantic proximity Read ↗

Arabidopsis thaliana FANCD2 Promotes Meiotic Crossover Formation.Semantic proximity Read ↗

Unleashing meiotic crossovers in hybrid plants.Semantic proximity Read ↗

FANCM-associated proteins MHF1 and MHF2, but not the other Fanconi anemia factors, limit meiotic crossovers.Semantic proximity Read ↗

AtPRD1 is required for meiotic double strand break formation in Arabidopsis thaliana.Semantic proximity Read ↗

Crossover control: A key to unlocking genetic diversity in plant breeding.Semantic proximity Read ↗

FIGNL1-containing protein complex is required for efficient homologous recombination repair.Semantic proximity Read ↗

The Fanconi anemia ortholog FANCM ensures ordered homologous recombination in both somatic and meiotic cells in Arabidopsis.Semantic proximity Read ↗

DNA methylation epigenetically silences crossover hot spots and controls chromosomal domains of meiotic recombination in Arabidopsis.Semantic proximity Read ↗

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