Article
DNA methylation epigenetically silences crossover hot spots and controls chromosomal domains of meiotic recombination in Arabidopsis.
Genes & development - 15 Oct 2015
Yelina Nataliya E, Lambing Christophe, Hardcastle Thomas J, Zhao Xiaohui, Santos Bruno, Henderson Ian R
Abstract excerpt
During meiosis, homologous chromosomes undergo crossover recombination, which is typically concentrated in narrow hot spots that are controlled by genetic and epigenetic information. Arabidopsis chromosomes are highly DNA methylated in the repetitive centromeres, which are also crossover-suppressed. Here we demonstrate that RNA-directed DNA methylation is sufficient to locally silence Arabidopsis euchromatic...
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