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Article

Efficient dual sgRNA-directed large gene deletion in rabbit with CRISPR/Cas9 system.

Cellular and molecular life sciences : CMLS - 1 Aug 2016

Song Yuning, Yuan Lin, Wang Yong, Chen Mao, Deng Jichao, Lv Qingyan, Sui Tingting, Li Zhanjun, Lai Liangxue

Abstract excerpt

The CRISPR RNA-guided Cas9 nuclease gene-targeting system has been extensively used to edit the genome of several organisms. However, most mutations reported to date have been are indels, resulting in multiple mutations and numerous alleles in targeted genes. In the present study, a large deletion of 105 kb in the TYR (tyrosinase) gene was generated in rabbit via a dual sgRNA-directed CRISPR/Cas9 system. The...

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Identifiers

PMID: 26817461
DOI: 10.1007/s00018-016-2143-z
PMCID: PMC11108552

Genes

TYR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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