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Article

EPHX1 rs1051740 T>C (Tyr113His) is strongly associated with acute myeloid leukemia and KMT2A rearrangements in early age.

Archives of toxicology - 1 Jun 2018

Brisson Gisele Dallapicola, de Almeida Lopes Bruno, Andrade Francianne Gomes, Dos Santos Bueno Filipe Vicente, Sardou-Cezar Ingrid, de Aguiar Gonçalves Bruno Alves, Terra-Granado Eugênia, Paraguassú-Braga Flávio Henrique, Pombo-de-Oliveira Maria S

Abstract excerpt

Experimental and epidemiological data have shown that acute myeloid leukemia in early-age (i-AML) originates prenatally. The risk association between transplacental exposure to benzene metabolites and i-AML might be influenced by genetic susceptibility. In this study, we investigated the relationship between genetic polymorphisms in CYP2E1, EPHX1, MPO, NQO1, GSTM1 and GSTT1 genes, and i-AML risk. The study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29605894
DOI: 10.1007/s00204-018-2198-8

Genes

EPHX1
GSTM1
GSTT1
MPO
NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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EPHX1 rs1051740 T>C (Tyr113His) is strongly associated with acute myeloid leukemia and KMT2A rearrangements in early age.PMID 29605894Read ↗

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