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Article

Association between polymorphisms of EPHX1 and XRCC1 genes and the risk of childhood acute lymphoblastic leukemia.

Archives of toxicology - 1 Mar 2012

Tumer Tugba Boyunegmez, Sahin Gurses, Arinç Emel

Abstract excerpt

Microsomal epoxide hydrolase, EPHX1, plays a central role in the detoxification of potentially genotoxic epoxide intermediates. In this study, we firstly aimed to investigate the relationship between EPHX1 Tyr113His and His139Arg variants, and the risk of incidence of childhood acute lymphoblasti...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Share to X-ray Repair Cross Complementing Protein 1

Source

Identifiers

PMID: 21983886
DOI: 10.1007/s00204-011-0760-8

Genes

EPHX1
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21983886-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Association between polymorphisms of EPHX1 and XRCC1 genes and the risk of childhood acute lymphoblastic leukemia.PMID 21983886Read ↗

Quantitative assessment of the influence of EPHX1 gene polymorphisms and cancer risk: a meta-analysis with 94,213 subjects.Semantic proximity Read ↗

EPHX1 Tyr113His and His139Arg polymorphisms in esophageal cancer risk: a meta-analysis.Semantic proximity Read ↗

Systematic review and meta-analysis of the relationship between EPHX1 polymorphisms and colorectal cancer risk.Semantic proximity Read ↗

Association between microsomal epoxide hydrolase 1 polymorphisms and susceptibility to esophageal cancer: a meta-analysis.Semantic proximity Read ↗

Systematic Review and Meta-Analysis of the Relationship between EPHX1 Polymorphisms and the Risk of Head and Neck Cancer.Semantic proximity Read ↗

Investigation of a possible relationship between EPHX1 gene polymorphisms and colorectal cancer in Turkish society.Semantic proximity Read ↗

Microsomal epoxide hydrolase (EPHX1), slow (exon 3, 113His) and fast (exon 4, 139Arg) alleles confer susceptibility to squamous cell esophageal cancer.Semantic proximity Read ↗

EPHX1 rs1051740 T>C (Tyr113His) is strongly associated with acute myeloid leukemia and KMT2A rearrangements in early age.Semantic proximity Read ↗

Association between esophageal cancer risk and EPHX1 polymorphisms: a meta-analysis.Semantic proximity Read ↗

The association of polymorphisms in DNA base excision repair genes XRCC1, OGG1 and MUTYH with the risk of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Lack of association between EPHX1 polymorphism and esophageal cancer risk: evidence from meta-analysis.Semantic proximity Read ↗

Putative EPHX1 enzyme activity is related with risk of lung and upper aerodigestive tract cancers: a comprehensive meta-analysis.Semantic proximity Read ↗

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