Article
Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study.
BMC cancer - 7 May 2013
Conesa-Zamora Pablo, Ruiz-Cosano Javier, Torres-Moreno Daniel, Español Ignacio, Gutiérrez-Meca María D, Trujillo-Santos Javier, Pérez-Ceballos Elena, González-Conejero Rocío, Corral Javier, Vicente Vicente, Pérez-Guillermo Miguel
Abstract excerpt
BACKGROUND: The interplay between genetic susceptibility and carcinogenic exposure is important in the development of haematopoietic malignancies. EPHX1, NQO1 and PON1 are three genes encoding proteins directly involved in the detoxification of potential carcinogens. METHODS: We have studied the prevalence of three functional polymorphisms affecting these genes rs1051740 EPHX1, rs1800566 NQO1 and rs662 PON1 in...
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