Article

Single-cell profiling of CAR-T CD19 cell phenotypes and immune system dynamics in pediatric BCP-ALL

2025-04-01

Abstract excerpt

<h4>Background</h4> Chimeric Antigen Receptor T-cell (CAR-T) therapy targeting CD19 has transformed the treatment of relapsed/refractory B-cell precursor acute lymphoblastic leukemia (BCP-ALL). However, the phenotypic heterogeneity of CAR+ T-cells and their interactions with the immune system remain poorly understood. Here, we characterize CAR+ T-cell subsets and persistence in patients receiving standard-of-care...

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Literature Corpus work: e437c924-7a01-5971-b1fa-28931bbd11d6
DOI: 10.1101/2025.03.27.645594

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