In Vivo Generation of CAR T Cells Selectively in Human CD4+ Lymphocytes

Abstract excerpt

T cells modified with CD19-specific chimeric antigen receptors (CARs) result in significant clinical benefit for leukemia patients but constitute a challenge for manufacturing. We have recently demonstrated the in vivo generation of CD19-CAR T cells using the CD8-targeted lentiviral vector (CD8-LV). In this study, we investigated the in vivo generation of CD4 + CAR T cells using CD4-targeted LV (CD4-LV)....

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