Automated Manufacture of Autologous CD19 CAR-T Cells for Treatment of Non-hodgkin Lymphoma.

doi:10.3389/fimmu.2020.01941

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Article

Automated Manufacture of Autologous CD19 CAR-T Cells for Treatment of Non-hodgkin Lymphoma.

Frontiers in immunology - 1 Jan 2020

Jackson Zachary, Roe Anne, Sharma Ashish Arunkumar, Lopes Filipa Blasco Tavares Pereira, Talla Aarthi, Kleinsorge-Block Sarah, Zamborsky Kayla, Schiavone Jennifer, Manjappa Shivaprasad, Schauner Robert, Lee Grace, Liu Ruifu, Caimi Paolo F, Xiong Ying, Krueger Winfried, Worden Andrew, Kadan Mike, Schneider Dina, Orentas Rimas, Dropulic Boro, Sekaly Rafick-Pierre, de Lima Marcos, Wald David N, Reese Jane S

Abstract excerpt

Chimeric antigen receptor T cells (CAR-T cell) targeting CD19 are effective against several subtypes of CD19-expressing hematologic malignancies. Centralized manufacturing has allowed rapid expansion of this cellular therapy, but it may be associated with treatment delays due to the required logistics. We hypothesized that point of care manufacturing of CAR-T cells on the automated CliniMACS Prodigy® device...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32849651
DOI: 10.3389/fimmu.2020.01941
PMCID: PMC7427107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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