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Genomic changes in an attenuated genotype I Japanese encephalitis virus and comparison with virulent parental strain.

Virus genes - 1 Jun 2018

Zhou Yuyong, Wu Rui, Feng Yao, Zhao Qin, Wen Xintian, Huang Xiaobo, Wen Yiping, Yan Qigui, Huang Yong, Ma Xiaoping, Han Xinfeng, Cao Sanjie

Abstract excerpt

Genotype I Japanese encephalitis virus (JEV) strain SCYA201201 was previously isolated from brain tissues of aborted piglets. In this study, we obtained an attenuated SCYA201201-0901 strain by serial passage of strain SCYA201201-1 in Syrian baby hamster kidney cells, combined with multiple plaque purifications and selection for virulence in mice. We investigated the genetic changes associated with attenuation by...

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PMID: 29605839
DOI: 10.1007/s11262-018-1559-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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