Article
Identification of mutations that occurred on the genome of Japanese encephalitis virus during the attenuation process.
Virus genes - 1 Apr 1991
Aihara S, Rao C M, Yu Y X, Lee T, Watanabe K, Komiya T, Sumiyoshi H, Hashimoto H, Nomoto A
Abstract excerpt
The total nucleotide sequences of the genomes of two Japanese encephalitis virus (JEV) strains, the attenuated vaccine strain SA14-14-2 and its parental virulent strain SA14, were determined by using the molecular cloning technique. The sequence analysis revealed that both virion RNA molecules were 10,976 nucleotides long with 95 and 585 flanking bases at the 5' and 3' untranslated sequences, respectively. A...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Capsid
- Cells, Cultured
- Cloning, Molecular
- Cricetinae
- Encephalitis Virus, Japanese
- Mice
- Molecular Sequence Data
- Mutation