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Phenotypic and genotypic characterization of the neurovirulence and neuroinvasiveness of a large-plaque attenuated Japanese encephalitis virus isolate.

Microbes and infection - 1 May 2003

Wu Suh-Chin, Lin Cheng-Wen, Lee Shiang-Chi, Lian Wei-Cheng

Abstract excerpt

The virulent phenotypes of Japanese encephalitis virus (JEV) can be divided into neuroinvasiveness (NI) and neurovirulence (NV). In this study, two JEV antigenic variants, CH2195LA (large-plaque, attenuated) and CH2195SA (small-plaque, non-attenuated), were passaged in suckling mice by intracerebral inoculation. Viruses at passage two and four were characterized in terms of NV and NI in weaning mice, as well as...

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PMID: 12758275
DOI: 10.1016/s1286-4579(03)00064-9

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