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Mutation of I176R in the E coding region weakens Japanese encephalitis virus neurovirulence, but not its growth rate in BHK-21 cells.

Archives of virology - 1 May 2018

Zhou Yuyong, Wu Rui, Zhao Qin, Chang Yung-Fu, Wen Xintian, Feng Yao, Huang Xiaobo, Wen Yiping, Yan Qigui, Huang Yong, Ma Xiaoping, Han Xinfeng, Cao Sanjie

Abstract excerpt

Previously, we isolated the Japanese encephalitis virus (JEV) strain SCYA201201. In this study, we passed the SCYA201201 strain in Syrian baby hamster kidney (BHK-21) cells 120 times to obtain the SCYA201201-0901 strain, which exhibited an attenuated phenotype in mice. Comparison of SCYA201201-0901 amino acid sequences with those of other JEV strains revealed a single mutation, I176R, in the E coding region....

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PMID: 29411136
DOI: 10.1007/s00705-018-3765-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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