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Article

Hidden genomic MHC disparity between HLA-matched sibling pairs in hematopoietic stem cell transplantation.

Scientific reports - 29 Mar 2018

Koskela Satu, Ritari Jarmo, Hyvärinen Kati, Kwan Tony, Niittyvuopio Riitta, Itälä-Remes Maija, Pastinen Tomi, Partanen Jukka

Abstract excerpt

Matching classical HLA alleles between donor and recipient is an important factor in avoiding adverse immunological effects in HSCT. Siblings with no differences in HLA alleles, either due to identical-by-state or identical-by-descent status, are considered to be optimal donors. We carried out a retrospective genomic sequence and SNP analysis of 336 fully HLA-A, -B, -DRB1 matched and 14 partially HLA-matched...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29599509
DOI: 10.1038/s41598-018-23682-y
PMCID: PMC5876349

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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