Article
Three-dimensional structure discrepancy between HLA alleles for effective prediction of aGVHD severity and optimal selection of recipient-donor pairs: a proof-of-concept study.
Oncotarget - 24 Nov 2015
Han Hongxing, Yuan Fang, Sun Yuying, Liu Jinfeng, Liu Shuguang, Luo Yuan, Liang Fei, Liu Nan, Long Juan, Zhao Xiao, Kong Fanhua, Xi Yongzhi
Abstract excerpt
The optimal selection of recipient-donor pair and accurate prediction of acute graft-versus-host disease (aGVHD) severity are always the two most crucial works in allogeneic hematopoietic stem cell transplantation (allo-HSCT), which currently rests mostly with HLA compatibility, the most polymorphic loci in the human genome, in clinic. Thus, there is an urgent need for a rapid and reliable quantitative system for...
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