Article
A descriptive study on isoniazid resistance-associated mutations, clustering and treatment outcomes of drug-resistant tuberculosis in a high burden country.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Jan 2024
Pinhata Juliana Maira Watanabe, Ferrazoli Lucilaine, Mendes Flávia de Freitas, Gonçalves Maria Gisele, Rabello Michelle Christiane da Silva, Ghisi Kelen Teixeira, Simonsen Vera, Cavalin Roberta Figueiredo, Lindoso Ana Angélica Bulcão Portela, de Oliveira Rosângela Siqueira
Abstract excerpt
PURPOSE: To describe katG and inhA mutations, clinical characteristics, treatment outcomes and clustering of drug-resistant tuberculosis (TB) in the State of São Paulo, southeast Brazil. METHODS: Mycobacterium tuberculosis isolates from patients diagnosed with drug-resistant TB were screened for mutations in katG and inhA genes by line probe assay and Sanger sequencing, and typed by IS6110-restriction...
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