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Article

The UGT2B28 Sex-steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression.

European urology - 1 Apr 2016

Belledant Anaïs, Hovington Hélène, Garcia Luciana, Caron Patrick, Brisson Hervé, Villeneuve Lyne, Simonyan David, Têtu Bernard, Fradet Yves, Lacombe Louis, Guillemette Chantal, Lévesque Eric

Abstract excerpt

BACKGROUND: Androgen inactivation occurs mainly through the glucuronidation conjugative reaction mediated by UDP-glucuronosyltransferases (UGTs). This metabolic process is involved in the control of systemic and local androgen bioavailability. OBJECTIVE: To examine the relationship among expression of the androgen-inactivating UGT2B28 enzyme, circulating steroid hormone levels, and clinical phenotype in prostate...

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Identifiers

PMID: 26215610
DOI: 10.1016/j.eururo.2015.06.054

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