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Establishment of a Large-Scale PDX Library of Head and Neck Cancers for Functional Precision Oncology.

Cancer medicine - 1 Feb 2026

Yanagi Hisano, Kuki Tomoki, Takimoto Tetsuya, Takabayashi Miki, Yamada Seiji, Yagi Chikako, Kiryu Yoshitake, Kurimoto Maki, Ishikawa Miho, Yoshida Arisa, Mizutani Yasuyoshi, Enomoto Atsushi, Suzuki Motoshi, Kawada Kenji, Kato Hisayuki, Tateya Ichiro, Saya Hideyuki, Watanabe Takashi

Abstract excerpt

BACKGROUND: Precision oncology leverages the molecular and genetic characteristics of tumors to enable accurate diagnosis and effective treatment selection. However, recent clinical trials have highlighted the limitations of current approaches and underscored the need to integrate static molecular profiling with functional analyses using patient-derived xenograft (PDX) models-particularly for cancers such as head...

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Antineoplastic Agents
Head and Neck Neoplasms
Mice
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precision Medicine

Xenograft Model Antitumor Assays

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PMID: 41709080
DOI: 10.1002/cam4.71521
PMCID: PMC12916448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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