Article
Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time.
Nature communications - 5 Sept 2017
Chia Shumei, Low Joo-Leng, Zhang Xiaoqian, Kwang Xue-Lin, Chong Fui-Teen, Sharma Ankur, Bertrand Denis, Toh Shen Yon, Leong Hui-Sun, Thangavelu Matan T, Hwang Jacqueline S G, Lim Kok-Hing, Skanthakumar Thakshayeni, Tan Hiang-Khoon, Su Yan, Hui Choo Siang, Hentze Hannes, Tan Iain B H, Lezhava Alexander, Tan Patrick, Tan Daniel S W, Periyasamy Giridharan, Koh Judice L Y, Gopalakrishna Iyer N, DasGupta Ramanuj
Abstract excerpt
Genomics-driven cancer therapeutics has gained prominence in personalized cancer treatment. However, its utility in indications lacking biomarker-driven treatment strategies remains limited. Here we present a "phenotype-driven precision-oncology" approach, based on the notion that biological response to perturbations, chemical or genetic, in ex vivo patient-individualized models can serve as predictive biomarkers...
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