Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Essential role for proteinase-activated receptor-2 in arthritis.

The Journal of clinical investigation - 1 Jan 2003

Ferrell William R, Lockhart John C, Kelso Elizabeth B, Dunning Lynette, Plevin Robin, Meek Stephen E, Smith Andrew J H, Hunter Gary D, McLean John S, McGarry Frances, Ramage Robert, Jiang Lu, Kanke Toru, Kawagoe Junichi

Abstract excerpt

Using physiological, pharmacological, and gene disruption approaches, we demonstrate that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in mediating chronic inflammation. Using an adjuvant monoarthritis model of chronic inflammation, joint swelling was substantially inhibited in PAR-2-deficient mice, being reduced by more than fourfold compared with wild-type mice, with virtually no histological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis
Share to Cartilage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelium

Share to In Situ Hybridization

Share to Models, Chemical

Share to Oligopeptides

Share to Receptors, Thrombin

Source

Open in PubMed Open full text

Identifiers

PMID: 12511586
DOI: 10.1172/JCI16913
PMCID: PMC151840

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Essential role for proteinase-activated receptor-2 in arthritis.PMID 12511586Read ↗

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): PAR-2 as a Potential Therapeutic TargetSemantic proximity Read ↗

Proteinase-activated Receptor-2 Gene Disruption Limits the Effect of Osteoarthritis on Cartilage in Mice: A Novel Target in Joint DegradationSemantic proximity Read ↗

Proteinase-Activated Receptor 2 (PAR2) Deficiency and Cardiovascular Regulation: Context-Dependent Effects on Inflammation and FibrosisSemantic proximity Read ↗

PAR2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis in Mice.Semantic proximity Read ↗

Profiling Gene Expression Induced by Protease-Activated Receptor 2 (PAR2) Activation in Human Kidney CellsSemantic proximity Read ↗

Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS signallingSemantic proximity Read ↗

Mapping transmembrane residues of proteinase activated receptor 2 (PAR2) that influence ligand-modulated calcium signaling.Semantic proximity Read ↗

Proteinase-activated receptor 2 activation promotes an anti-inflammatory and alternatively activated phenotype in LPS-stimulated murine macrophages.Semantic proximity Read ↗

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skinSemantic proximity Read ↗

Identification of Proteinase Activated Receptor (PAR) cleaving enzymes in human osteoarthritis knee joint synovial fluidsSemantic proximity Read ↗

New insights into the regulation of inflammation by adenosine.Semantic proximity Read ↗

Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.