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Article

Attenuated vasodilator effectiveness of protease-activated receptor 2 agonist in heterozygous par2 knockout mice.

PloS one - 1 Jan 2013

Hennessey John C, McGuire John J

Abstract excerpt

Studies of homozygous PAR2 gene knockout mice have described a mix of phenotypic effects in vitro and in vivo. However, there have been few studies of PAR2 heterozygous (wild-type/knockout; PAR2-HET) mice. The phenotypes of many hemi and heterozygous transgenic mice have been described as intermediates between those of wild-type and knockout animals. In our study we aimed to determine the effects of intermediary...

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Identifiers

PMID: 23409098
DOI: 10.1371/journal.pone.0055965
PMCID: PMC3567012

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