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Article

Polymorphisms Within RYR3 Gene Are Associated With Risk and Age at Onset of Hypertension, Diabetes, and Alzheimer's Disease.

American journal of hypertension - 11 Jun 2018

Gong Shaoqing, Su Brenda Bin, Tovar Hugo, Mao ChunXiang, Gonzalez Valeria, Liu Ying, Lu Yongke, Wang Ke-Sheng, Xu Chun

Abstract excerpt

BACKGROUND: Hypertension affects 33% of Americans while type 2 diabetes and Alzheimer's disease (AD) affect 10% of Americans, respectively. Ryanodine receptor 3 gene (RYR3) codes for the RYR which functions to release stored endoplasmic reticulum calcium ions (Ca2+) to increase intracellular Ca2+ concentration. Increasing studies demonstrate that altered levels of intracellular Ca2+ affect cardiac contraction,...

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Source

Identifiers

PMID: 29590321
DOI: 10.1093/ajh/hpy046

Genes

RYR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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