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Article

Evidence supporting a role for the calcium-sensing receptor in Alzheimer disease.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jul 2009

Conley Yvette P, Mukherjee Ankur, Kammerer Candace, DeKosky Steven T, Kamboh M Ilyas, Finegold David N, Ferrell Robert E

Abstract excerpt

The calcium-sensing receptor (CASR) is a G-protein coupled, transmembrane receptor that responds to changes in Ca(2+) levels. We hypothesized that the CASR could have a role in Alzheimer disease (AD) given expression of the CASR in brain, knowledge that calcium dysregulation promotes susceptibility to neuronal cell damage, the important role that the CASR plays in calcium regulation, and the fact that systemic...

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Identifiers

PMID: 19035514
DOI: 10.1002/ajmg.b.30896
PMCID: PMC3062902

Genes

CASR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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