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Article

Reappraisal of the genetic heterogeneity of sessile serrated adenoma/polyp.

Histopathology - 1 Oct 2018

Cho Hourin, Hashimoto Taiki, Yoshida Hiroshi, Taniguchi Hirokazu, Ogawa Reiko, Mori Taisuke, Hiraoka Nobuyoshi, Saito Yutaka, Sekine Shigeki

Abstract excerpt

AIMS: Sessile serrated adenoma/polyp (SSA/P) is regarded as a genetically homogeneous entity, with most lesions harbouring the BRAF V600E mutation. The present study aimed to reappraise the genetic heterogeneity of SSA/Ps and its clinicopathological significance. METHODS AND RESULTS: We performed next-generation sequencing of 272 SSA/Ps without dysplasia and evaluated morphological and molecular features...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29920740
DOI: 10.1111/his.13688

Genes

BRAF
KRAS
NRAS

Variants

Provenance

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