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Article

A mutant O-GlcNAcase enriches Drosophila developmental regulators.

Nature chemical biology - 1 Aug 2017

Selvan Nithya, Williamson Ritchie, Mariappa Daniel, Campbell David G, Gourlay Robert, Ferenbach Andrew T, Aristotelous Tonia, Hopkins-Navratilova Iva, Trost Matthias, van Aalten Daan M F

Abstract excerpt

Protein O-GlcNAcylation is a reversible post-translational modification of serines and threonines on nucleocytoplasmic proteins. It is cycled by the enzymes O-GlcNAc transferase (OGT) and O-GlcNAc hydrolase (O-GlcNAcase or OGA). Genetic approaches in model organisms have revealed that protein O-GlcNAcylation is essential for early embryogenesis. The Drosophila melanogaster gene supersex combs (sxc), which encodes...

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Identifiers

PMID: 28604694
DOI: 10.1038/nchembio.2404
PMCID: PMC7611224

Genes

OGT
OGA

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