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Article

Detection of renin lineage cell transdifferentiation to podocytes in the kidney glomerulus with dual lineage tracing.

Kidney international - 1 May 2018

Eng Diana G, Kaverina Natalya V, Schneider Remington R S, Freedman Benjamin S, Gross Kenneth W, Miner Jeffrey H, Pippin Jeffrey W, Shankland Stuart J

Abstract excerpt

Understanding of cellular transdifferentiation is limited by the technical inability to track multiple lineages in vivo. To overcome this we developed a new tool to simultaneously fate map two distinct cell types in the kidney, and genetically test whether cells of renin lineage (CoRL) can transdifferentiate to a podocyte fate. Ren1cCreER/tdTomato/Nphs1-FLPo/FRT-EGFP mice (CoRL-PODO mice) were generated by...

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Identifiers

PMID: 29580637
DOI: 10.1016/j.kint.2018.01.014
PMCID: PMC5876716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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