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Article

Cells of renin lineage take on a podocyte phenotype in aging nephropathy.

American journal of physiology. Renal physiology - 15 May 2014

Pippin Jeffrey W, Glenn Sean T, Krofft Ronald D, Rusiniak Michael E, Alpers Charles E, Hudkins Kelly, Duffield Jeremy S, Gross Kenneth W, Shankland Stuart J

Abstract excerpt

Aging nephropathy is characterized by podocyte depletion accompanied by progressive glomerulosclerosis. Replacement of terminally differentiated podocytes by local stem/progenitor cells is likely a critical mechanism for their regeneration. Recent studies have shown that cells of renin lineage (CoRL), normally restricted to the kidney's extraglomerular compartment, might serve this role after an abrupt depletion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24647714
DOI: 10.1152/ajprenal.00699.2013
PMCID: PMC4024732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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