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Article

Permanent Genetic Tagging of Podocytes

29 Jun 2005

Abstract excerpt

Injured podocytes lose differentiation markers. Therefore, the true identity of severely injured podocytes remains unverified. A transgenic mouse model equipped with a podocyte-selective injury induction system was established. After induction of podocyte injury, mice rapidly developed glomerulosclerosis, with downregulation of podocyte marker proteins. Proliferating epithelial cells accumulated within Bowman's...

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Identifiers

PMID: 15987751
DOI: 10.1681/asn.2004121134

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